P12-42 Comparative study of the cytotoxicity of hydroxyapatite, tricalcium phosphate and calcium phosphate nanomaterials on Panc-1 and HEK293 Cell Line

While improved surgical techniques, post-operative care, and immunosuppression regimens have reduced morbidity mortality associated with orthotopic liver transplantation (OLT), further improvement of outcomes requires personalized treatment a better understanding genomic mechanisms involved. Gene expression profiles ischemia/reperfusion (I/R) injury, regeneration, rejection, may suggest for development predictive tools treatments. The is unique in its regenerative potential, recovering lost mass function after injury from ischemia, resection, rejection. I/R an inevitable consequence perfusion cessation, cold storage, reperfusion, regulated by the interaction immune system, inflammatory cytokines, microcirculatory blood flow liver. Rejection, common complication, mediated recipient's system through T-cell-dependent responses activating proinflammatory apoptotic pathways. Characterizing distinctive gene signatures these events can identify therapies to reduce promote improve outcomes. certain markers regeneration been observed animals, many are unverified human studies. Further investigation new technology offers promise, but continues pose significant challenge. An overview current fund knowledge this area reviewed.